supercritical fluid chromatograph / UV / photodiode array / laboratory

The effect of the chiral compounds is the key factor in the pharmaceutical industry, and in order to evaluate the enantiomer, the chiral separation is taken up as a main theme. As a solution, Supercritical Fluid Chromatography (SFC) is drawing attention from many researchers.

Since the separation capacity of SFC is higher than the one of HPLC, the SFC is powerful tool for separating the chiral compounds which is hard to separate by using HPLC.

SFC-4000 – Analytical systems

The physical characteristics exhibited by supercritical fluid include a diffusion coefficient of dissolved molecules that is a hundred times greater than it is in liquid and a viscosity that is at least one digit smaller. A SFC system, which employs such a medium as a mobile phase, can be expected to serve as a separation analysis method that can rapidly perform separation without any degradation in separation efficiency, even at fast flow rates, due to a rapid mass transfer inside the column when compared with high-speed liquid chromatography that uses liquid as the mobile phase.

SFC-4000 – Preparative systems

The Semi-Prep SFC and the Prep SFC system are applied to separation and purification with high recovery. When carbon dioxide is used as the medium, gasification will occur simply by keeping the separated and fractionated sample at an atmospheric pressure, making this one of the techniques capable of highly efficient refining with few post-processing hassles, such as elimination solvents after preparative isolation. This offers a host of advantages, including cost cuts related to the expense of purchasing solvents and discarding organic solvents among other things.